Macrophages are key immune effector cells. They display remarkable plasticity and can change their physiology in response to environmental stimuli, giving rise to different populations of cells with distinct functions. Depending on circumstances, activation of macrophages can result in enhanced microbicidal or tumoricidal capacity, wound-healing activity or differentiation into regulatory macrophages'.
Protein concentration of unprocessed VDTP preparation has been determined by Bradford assay (IB-16.05.00). After processing, VDTP final solutions were prepared in concentrations: 167 ng/ml; 1,000 ng/mI and 3,334 ng/mI (±10%) in relation to initial concentration.
Each batch is accompanied by the product quality certificate (certificate of analysis) according to industry standards. They contain: composition, concentration of active ingredient, dates of production and analysis, impurities level, endotoxin level by LAL assay, sterility by European Pharmacopeia.
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In order to test whether components of Omnia inhibit cancer cells proliferation, we treated MCF-7 cells (cell line derived from human breast cancer) with albumin conjugated Omnia. Albumin is necessary as a transporter of oleic acid (under in vitro conditions). The assay used in the experiment is colorimetric cell proliferation assay, where absorbance at a specific wavelength is proportional to cells viability.
1. Formulation and characteristics Formulation and characteristic parameters have been confirmed organoleptically. 2. Concentration Omnia Drops contain 22.8 mg/ml of chondrotin sulphate ingredient. Omnia Drops contain —12.5 mg/ml of oleic acid. 3. Activity Omnia Drops contain 100 IU/m1 of vitamin D2. Certificate of analysis is attached to the report. Omnia Drops contain 1018 IU/ml of vitamin D3.
Anticancer efficacy of Vitamin D Transport Protein (VDTP) can be ascribed at least to three biological properties of the molecule: 1) activation of tumoricidal macrophages; 2) inhibition of tumor-induced angiogenesis and 3) direct inhibition of cancer cell proliferation, migration and metastatic potential.
Omnia® is a sulphate derivative, that contains no proteins and therefore is more stable in many ways. An example of this is that a sulphate is not affected by the stomach acid. Therefore it can be passed more easily through the gastrointestinal tract, which improves bioavailability and transportation.